Kushenol K(Synonyms: 苦参醇K)

发表于由

天然产物 黄酮类 Flavonoids

Kushenol K (Synonyms: 苦参醇K)

Kushenol K，一种从 Sophora flavescens 中提取的黄酮类抗氧化剂。Kushenol K 是 CYP3A4 的抑制剂，Ki 值为 1.35 μM。Kushenol K 对 HSV-2 具有较弱的抗病毒活性 (EC50 为 147 μM)。Kushenol K 还抑制 SGLT1 和 SGLT2 的活性。

Kushenol K(Synonyms: 苦参醇K)

Kushenol K Chemical Structure

CAS No. : 101236-49-1

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生物活性

Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3].

IC50 & Target[1][2][3]

HSV-2

147 μM (EC50)

CYP3A4

1.35 μM (Ki)

SGLT

 

体外研究
(In Vitro)

When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC50 values of 1.62 µM[1].
At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

472.53

Formula

C26H32O8
CAS 号

101236-49-1
中文名称

苦参醇K；苦参醇 K
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yannan Li, et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.

    [2]. E R Woo, et al. A new prenylated flavonol from the roots of Sophora flavescens. J Nat Prod. 1998 Dec;61(12):1552-4.

    [3]. Seizo Sato, et al. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9.