Bakkenolide B

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Bakkenolide B 

Bakkenolide B 是从 petasites japonicas 叶片中分离出来的,具有抗过敏和抗炎作用。 Bakkenolide B 可用于研究哮喘。

Bakkenolide B

Bakkenolide B Chemical Structure

CAS No. : 18455-98-6

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生物活性

Bakkenolide B is isolated from petasites japonicas leaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma[1].

体外研究
(In Vitro)

Bakkenolide B (0-100 μg/ml; pretreatment 30 mins) inhibits antigen-induced β-hexosamidase release from RBL2H3 mast cells in a concentration-dependent manner[1].
Bakkenolide B (0-10 μg/ml; 1 h later stimulated with LPS) strongly inhibits the gene inductions of inducible nitric oxide synthase and cyclooxygenase-2 in a concentration-dependent manner in mouse peritoneal macrophages[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Mouse peritoneal macrophages
Concentration: 0 μg/ml; 1 μg/ml; 3 μg/ml; 5 μg/ml; 10 μg/ml
Incubation Time: 1 h later stimulated with LPS
Result: Decreased iNOS and cox-2 protein expression.

体内研究
(In Vivo)

Bakkenolide B (intraperitoneal injection; 1 mg/ml; 1 h before ovalbumin nebulization on days 28, 29, and 30) strongly inhibits the accumulation of eosinophils, macrophages, and lymphocytes to bronchoalveolar lavage fluid (BALF) in ovalbumin-induced asthma mice[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ovalbumin-induced asthma mice[1]
Dosage: 1 mg/ml
Administration: Intraperitoneal injection; 1 h before ovalbumin nebulization on days 28, 29, and 30
Result: Exhibited anti-allergic effects in mice.

分子量

390.47

Formula

C22H30O6

CAS 号

18455-98-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Lee KP, et al. Anti-allergic and anti-inflammatory effects of bakkenolide B isolated from Petasites japonicus leaves.J Ethnopharmacol. 2013 Jul 30;148(3):890-4.

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