Polygodial(Synonyms: Poligodial; Tadeonal)

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Polygodial (Synonyms: Poligodial; Tadeonal)

Polygodial (Poligodial) 是一种抗真菌 (antifungal) 增强剂。Polygodial 是一种倍半萜,具有抗痛觉过敏的作用。

Polygodial(Synonyms: Poligodial;  Tadeonal)

Polygodial Chemical Structure

CAS No. : 6754-20-7

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生物活性

Polygodial (Poligodial) is an antifungal potentiator[1]. Polygodial is a sesquiterpene with anti-hyperalgesic properties[2].

体外研究
(In Vitro)

Polygodial exhibits fungicidal activity against Saccharomyces cerevisiaeCandida albicans, and other fungal pathogens in standardized susceptibility tests (NCCLS). Polygodial (12.5 μg/mL, 3 hours) induces significant shrinkage compared to controls in Saccharomyces cerevisiae cells with the minimum fungicidal concentration (MFC) for 106 CFU/mL in RPMI 1640 medium[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: S. cerevisiae cells
Concentration: 12.5 μg/mL
Incubation Time: 3 hours
Result: Treated cells exhibited significant shrinkage compared to controls, and the organization of subcellular organelles appears either disrupted or compacted.

体内研究
(In Vivo)

Polygodial is a sesquiterpene isolated from the barks of Drymis winteri (Winteraceae). Polygodial (0.5 to 10 mg/kg; 0.5 h; given by i.p. route to mice) induces significant, dose-related and almost complete inhibition of Acetic acid, Kaolin and Zymosan-induced abdominal constrictions. The calculated mean ID50 values are 0.8, 2.1 and 2.6 mg/kg and maximal inhibitions of 90.0±3.0, 98.0±1.0 and 97.0±2.0 %, against Acetic acid, Kaolin and Zymosan, respectively. Polygodial is about 14- to 27-fold more potent than the hydroalcoholic extract (HE) at the ID50 level[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Non-fasted male Swiss mice (20-30 g) or male Wistar rats (150-180 g)[2]
Dosage: 0.1 to 10 mg/kg
Administration: Injected i.p. 0.5 h before the injection of irritant substances
Result: Produced significant inhibition of Acetic acid, Kaolin and Zymosan-induced writhing in mice.

分子量

234.33

Formula

C15H22O2

CAS 号

6754-20-7

中文名称

蓼二醛

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. I Kubo, et al. Polygodial, an antifungal potentiator. J Nat Prod. Jan-Feb 1988;51(1):22-9.

    [2]. G L Mendes, et al. Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae). Life Sci. 1998;63(5):369-81.

    [3]. C S Lunde, et al. Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2000 Jul;44(7):1943-53.

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