Saikogenin A(Synonyms: 柴胡皂苷元A)

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Saikogenin A (Synonyms: 柴胡皂苷元A) 纯度: 98.31%

Saikogenin A 可从中药柴胡中提取,是一种二肽基肽酶 IV (DPP-IV) 抑制剂。

Saikogenin A(Synonyms: 柴胡皂苷元A)

Saikogenin A Chemical Structure

CAS No. : 5092-09-1

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生物活性

Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.

IC50 & Target

DPP-IV[1]

体外研究
(In Vitro)

Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. Saikogenin A is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema. The anti-inflammatory action of Saikogenin A are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

472.70

Formula

C30H48O4

CAS 号

5092-09-1

中文名称

柴胡皂苷元A

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Pharmaceutical application of saikogenin A. CN107375300A.

    [2]. Cheng JT, et al. Anti-inflammatory effect of Saikogenin A. Biochem Pharmacol. 1986 Aug 1;35(15):2483-7.