Endothelin-3, human, mouse, rabbit, rat TFA(Synonyms: Endothelin 3 (Rat,Human) (TFA))

发表于由

Endothelin-3, human, mouse, rabbit, rat TFA;(Synonyms: Endothelin 3 (Rat,Human) (TFA)) 纯度: 99.66%

Endothelin-3, human, mouse, rabbit, rat TFA 是由21个氨基酸组成的血管活性肽，可与G蛋白连接的跨膜受体，ET-RA 和ET-RB 结合。

Endothelin-3, human, mouse, rabbit, rat TFA (Synonyms: Endothelin 3 (Rat,Human) (TFA))

Endothelin-3, human, mouse, rabbit, rat TFA Chemical Structure

规格 价格 是否有货 数量
500 μg ￥1800 In-stock
1 mg ￥2800 In-stock
5 mg ￥9800 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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Endothelin-3, human, mouse, rabbit, rat TFA 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

IC50 & Target

ET-RA, ET-RB[1]
分子量

2757.07

Formula

C123H169F3N26O35S4
Sequence

Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp(Disulfide bridge: Cys1-Cys15, Cys3-Cys11)
Sequence Shortening

CTCFTYKDKECVYYCHLDIIW(Disulfide bridge: Cys1-Cys15, Cys3-Cys11)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (<50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Skovsted GF, et al. Endothelin-1 and Endothelin-3 Regulate Endothelin Receptor Expression in Rat Coronary Arteries. Basic Clin Pharmacol Toxicol. 2015 Nov;117(5):297-305.