Neuromedin B(Synonyms: 神经介素 B)

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Neuromedin B;(Synonyms: 神经介素 B) 纯度: 98.08%

Neuromedin B 是一种含10个氨基酸的神经肽，属于蛙肽家族，为铃蟾肽相关肽。

Neuromedin Bamp;;(Synonyms: 神经介素 B)

Neuromedin B Chemical Structure

CAS No. : 87096-84-2

规格 价格 是否有货 数量
1 mg ￥800 In-stock
5 mg ￥3100 In-stock
10 mg ￥5400 In-stock
25 mg ￥11000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Neuromedin B 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.

IC50 Target

Human Endogenous Metabolite

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体外研究
(In Vitro)

Potency to stimulate contraction of rat uterine smooth muscle, that is used as bioassay for isolation of Neuromedin B (NMB), is compared with Bombesin (BN). The relative potency, calculated on molar basis by taking BN as 100, is 48% for GRP and 4.9% for NMB. NMB also has contractile activity on rat stomach strip, but the potency (ratio of peptide concentration required to elicit 50% maximum response; EC50) is only 5% of BN (EC50 of BN/EC50 of NMB) and about 10% of GRP (EC50 of GRP/ EC50 of NMB)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Potencies of NMB and GRP for smooth muscle contraction of fundus in wild-type and NMB-R-deficient mice with ED50 of 14.4±2.3 (n=8) and 10.9±2.3 (n=8) in wild-type mice and NMB-R-deficient mice, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1132.29

Formula

C52H73N15O12S
CAS 号

87096-84-2
Sequence

Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2
Sequence Shortening

GNLWATGHFM-NH2
中文名称

神经介素 B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 12.5 mg/mL (11.04 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8832 mL 4.4158 mL 8.8317 mL
5 mM 0.1766 mL 0.8832 mL 1.7663 mL
10 mM 0.0883 mL 0.4416 mL 0.8832 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Ohki-Hamazaki H. Neuromedin B. Prog Neurobiol. 2000 Oct;62(3):297-312.