Tyr-Gly-Gly-Phe-Met-OH(Synonyms: 蛋氨酸脑啡肽 Met-Enkephalin Methionine enkephalin)

Tyr-Gly-Gly-Phe-Met-OH;(Synonyms: 蛋氨酸脑啡肽; Met-Enkephalin; Methionine enkephalin) 纯度: 98.07%

Tyr-Gly-Gly-Phe-Met-OH 通过结合阿片样物质受体 (opioid receptor),可调控人类免疫功能,抑制肿瘤生长。

Tyr-Gly-Gly-Phe-Met-OHamp;;(Synonyms: 蛋氨酸脑啡肽; Met-Enkephalin;  Methionine enkephalin)

Tyr-Gly-Gly-Phe-Met-OH Chemical Structure

CAS No. : 58569-55-4

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10;mM;*;1 mL in Water ¥550 In-stock
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50 mg ¥1600 In-stock
100 mg ¥2600 In-stock
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Tyr-Gly-Gly-Phe-Met-OH 相关产品

bull;相关化合物库:

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生物活性

Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.

IC50 Target

Opioid Receptor[1].

体外研究
(In Vitro)

Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

573.66

Formula

C27H35N5O7S

CAS 号

58569-55-4

Sequence

Tyr-Gly-Gly-Phe-Met

Sequence Shortening

YGGFM

中文名称

蛋氨酸脑啡肽

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : ≥ 40 mg/mL (69.73 mM)

H2O : 6.67 mg/mL (11.63 mM; Need ultrasonic)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7432 mL 8.7160 mL 17.4319 mL
5 mM 0.3486 mL 1.7432 mL 3.4864 mL
10 mM 0.1743 mL 0.8716 mL 1.7432 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Zhao D, et al. Methionine enkephalin, its role in immunoregulation and cancer therapy. Int Immunopharmacol. 2016 Feb 23. pii: S1567-5769(16)30050-9.