Gap19 TFA; 纯度: 95.11%
Gap19 TFA 是一种衍生自 Cx43 细胞质环 (CL) 九个氨基酸的肽,一种有效的,选择性连接蛋白 43 (Cx43) 半通道阻滞剂。Gap19 TFA 可以防止 C 末端 (CT) 与 CL 的分子内相互作用。Gap19 TFA 不阻断 GJ 通道或 Cx40/pannexin-1 半通道。Gap19 TFA 对心肌具有保护作用。
Gap19 TFA Chemical Structure
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
1 mg | ¥1500 | In-stock | |
5 mg | ¥4500 | In-stock | |
10 mg | ¥7500 | In-stock | |
50 mg | ; | 询价 | ; |
100 mg | ; | 询价 | ; |
* Please select Quantity before adding items.
Gap19 TFA 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- Anti-Cardiovascular Disease Compound Library
- Cytoskeleton Compound Library
- Peptide Library
生物活性 |
Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial[1][2]. |
IC50 Target |
Cx43 Hemichannel[1] |
||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
体外研究 (In Vitro) |
Gap19 TFA (250 μM; for 30 min ) decreases mitochondrial potassium uptake[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||||||
体内研究 (In Vivo) |
Gap19 TFA (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
|
||||||||||||||||
分子量 |
1275.46 |
||||||||||||||||
Formula |
C57H97F3N14O15 |
||||||||||||||||
Sequence Shortening |
KQIEIKKFK |
||||||||||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||
储存方式 |
Sealed storage, away from moisture
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture) |
||||||||||||||||
溶解性数据 |
In Vitro:;
DMSO : 100 mg/mL (78.40 mM; Need ultrasonic) H2O : 100 mg/mL (78.40 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
||||||||||||||||
参考文献 |
|