S961 acetate

S961 acetate; 纯度: 99.52%

S961 acetate 是一种高亲和力的胰岛素受体 (insulin receptor, IR) 拮抗剂,对 HIR-A,HIR-B 和人胰岛素样生长因子 I 受体 (HIGF-IR) 的 IC50 分别为 0.048,0.027 和 630 nM。

S961 acetateamp;;

S961 acetate Chemical Structure

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S961 acetate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

S961 acetate is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively[1].

体外研究
(In Vitro)

S961 also shows high-affinity to Rat IR and Pig IR with IC50s of 0.056 nM and 0.084 nM in PEG-assay, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

4864.18

Formula

C213H301N55O72S2

Sequence Shortening

GSLDESFYDWFERQLGGGSGGSSLEEEWAQIQCEVWGRGCPSY (Disulfide bridge: Cys33-Cys40)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

H2O : 1.79 mg/mL (0.37 mM; ultrasonic and adjust pH to 8 with NaOH)

参考文献
  • [1]. Schäffer L, et al. A novel high-affinity peptide antagonist to the insulin receptor. Biochem Biophys Res Commun. 2008 Nov 14;376(2):380-3.