Oxytocin(Synonyms: 催产素 缩宫素 α-Hypophamine Oxytocic hormone)

Oxytocin;(Synonyms: 催产素; 缩宫素; α-Hypophamine; Oxytocic hormone)

Oxytocin (α-Hypophamine; Oxytocic hormone) 是一种多效的下丘脑肽 (hypothalamic peptide),有助于分娩、哺乳和亲社会行为。Oxytocin 可以作为一种压力应对分子,具有抗炎、抗氧化剂和保护作用,特别是在面对逆境或创伤时。

Oxytocinamp;;(Synonyms: 催产素; 缩宫素; α-Hypophamine;  Oxytocic hormone)

Oxytocin Chemical Structure

CAS No. : 50-56-6

规格 价格 是否有货
10;mM;*;1 mL in DMSO ¥3600 询问价格 货期
2 mg ¥650 询问价格 货期

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Oxytocin 的其他形式现货产品:

Oxytocin acetate

生物活性

Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma[1][2].

IC50 Target

Human Endogenous Metabolite

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体内研究
(In Vivo)

During the LMA task, rat core body temperature are modestly decreased. Oxytocin (subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose) produces significantly greater hypothermia (at 0.3 mg/kg) than either saline or the two lower doses of oxytocin. Oxytocin at 0.3 mg/kg produces a significantly greater decrease in temperature than vehicle between 15-60 min post injection, whereas 0.1 mg/kg slightly decreases temperature at the 30 min time point only[1].
Oxytocin (0.1 mg/kg) engages in significantly more body sniffing and ano-genital sniffing compared with saline controls. It also increases the total time spent in social interaction (71.6±4.3 s), compared to those receiving vehicle (56.9±4.1 s)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fifty-six male Lister-hooded rats (150-200 g)[1]
Dosage: 0.1 mg/kg-0.3 mg/kg
Administration: Subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose
Result: Produced significantly greater hypothermia (at 0.3 mg/kg) than the saline group.

Clinical Trial

分子量

1007.19

Formula

C43H66N12O12S2

CAS 号

50-56-6

Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge:Cys1-Cys6)

Sequence Shortening

CYIQNCPLG-NH2 (Disulfide bridge:Cys1-Cys6)

中文名称

催产素;缩宫素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 100 mg/mL (99.29 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9929 mL 4.9643 mL 9.9286 mL
5 mM 0.1986 mL 0.9929 mL 1.9857 mL
10 mM 0.0993 mL 0.4964 mL 0.9929 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Shivali Kohli, et al. Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumben dopamine release in rats. Neuropsychopharmacology. 2019 Jan;44(2):295-305.

    [2]. C Sue Carter, et al. Is Oxytocin “Nature’s Medicine”? Pharmacol Rev. 2020 Oct;72(4):829-861.