TRAP-6(Synonyms: PAR-1 agonist peptide Thrombin Receptor Activator Peptide 6)

发表于由

TRAP-6;(Synonyms: PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6) 纯度: 99.74%

TRAP-6 (PAR-1 agonist peptide)，一种多肽片段，是选择性的蛋白酶激活受体 1 (PAR1) 激动剂。TRAP-6 通过凝血酶受体激活人血小板。TRAP-6 对 PAR4 无活性。

TRAP-6amp;;(Synonyms: PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6)

TRAP-6 Chemical Structure

CAS No. : 141136-83-6

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ￥1760 In-stock
10 mg ￥1600 In-stock
25 mg ￥3520 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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TRAP-6 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Immunology/Inflammation Compound Library
  • Peptidomimetic Library
  • Targeted Diversity Library
  • Peptide Library

生物活性

TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4[1].

IC50 Target

PAR1[1]
体外研究
(In Vitro)

TRAP-6 (0.01-10 μM) triggers calcium mobilization in Xenopus oocytes heterologously expressing PAR1[1].
TRAP-6 (0.01-10 μM; 30 min) activates human platelets[1].
TRAP-6 (100 μM) does not cause the platelets of rabbits or rats to change shape, aggregate, release granule contents, or form thromboxane[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

TRAP (1 mg/kg; i.v.) produces a biphasic response in blood pressure in inactin-anesthetized rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

748.87

Formula

C34H56N10O9
CAS 号

141136-83-6
Sequence

Ser-Phe-Leu-Leu-Arg-Asn
Sequence Shortening

SFLLRN
中文名称

凝血酶受体激活肽6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (133.53 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3353 mL 6.6767 mL 13.3535 mL
5 mM 0.2671 mL 1.3353 mL 2.6707 mL
10 mM 0.1335 mL 0.6677 mL 1.3353 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Kahn ML, et, al. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar;103(6):879-87.

    [2]. Kinlough-Rathbone RL, et, al. Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets. Blood. 1993 Jul 1;82(1):103-6.

    [3]. Chintala MS, et, al. Disparate effects of thrombin receptor activating peptide on platelets and peripheral vasculature in rats. Eur J Pharmacol. 1998 May 22;349(2-3):237-43.