NFAT Inhibitor-1(Synonyms: VIVIT peptide)

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NFAT Inhibitor-1;(Synonyms: VIVIT peptide) 纯度: 98.89%

NFAT Inhibitor (VIVIT peptide) 是一种 NFAT 的细胞渗透性肽抑制剂，可选择性抑制钙调磷酸酶介导的 NFAT 脱磷酸作用。

NFAT Inhibitor-1amp;;(Synonyms: VIVIT peptide)

NFAT Inhibitor-1 Chemical Structure

CAS No. : 249537-73-3

规格 价格 是否有货 数量
1 mg ￥700 In-stock
5 mg ￥2800 In-stock
10 mg ￥5100 In-stock
25 mg ￥9900 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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NFAT Inhibitor-1 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

NFAT Inhibitor (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT[1][2].

IC50 Target

Nuclear factor of activated Tcells (NFAT)[1][2]
体外研究
(In Vitro)

NFAT Inhibitor treatment significantly inhibits nuclear translocation of NFATc1 for 24 hours. Long-term treatment with VIVIT significantly inhibits the cytoplasmic levels of cathepsin K, TRAP, and MMP-9[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Human peripheral blood CD14+ monocytes
Concentration: 10 μM
Incubation Time: 24 hours or 21 days
Result: Short-term treatment with 10 μM, significantly inhibited nuclear translocation of NFATc1. Long-term treatment, significantly inhibited the cytoplasmic levels of cathepsin K, TRAP, and MMP-9.

分子量

1685.94

Formula

C75H120N20O22S
CAS 号

249537-73-3
Sequence

Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu
Sequence Shortening

MAGPHPVIVITGPHEE
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (59.31 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.5931 mL 2.9657 mL 5.9314 mL
5 mM 0.1186 mL 0.5931 mL 1.1863 mL
10 mM 0.0593 mL 0.2966 mL 0.5931 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Aramburu J, et al. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science. 1999 Sep 24;285(5436):2129-33.

    [2]. Ma JD, et al. Activation of the Peroxisome Proliferator-Activated Receptor γ Coactivator 1β/NFATc1 Pathway in Circulating Osteoclast Precursors Associated With Bone Destruction in Rheumatoid Arthritis. Arthritis Rheumatol. 2019 Aug;71(8):1252-1264.