Oxytocin acetate(Synonyms: 醋酸催产素 醋酸缩宫素 α-Hypophamine acetate Oxytocic hormone acetate)

发表于由

Oxytocin acetate;(Synonyms: 醋酸催产素; 醋酸缩宫素; α-Hypophamine acetate; Oxytocic hormone acetate) 纯度: ge;99.0%

Oxytocin acetate 是一种多效的下丘脑肽 (hypothalamic peptide)，有助于分娩、哺乳和亲社会行为。Oxytocin acetate 可以作为一种压力应对分子，具有抗炎、抗氧化剂和保护作用，特别是在面对逆境或创伤时。

Oxytocin acetateamp;;(Synonyms: 醋酸催产素; 醋酸缩宫素; α-Hypophamine acetate; Oxytocic hormone acetate)

Oxytocin acetate Chemical Structure

CAS No. : 6233-83-6

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in DMSO ￥763 In-stock
5 mg ￥450 In-stock
10 mg ￥650 In-stock
50 mg ￥1200 In-stock
100 mg ￥2000 In-stock
200 mg ￥3500 In-stock
500 mg ￥7000 In-stock
1 g ; 询价 ;
5 g ; 询价 ;

* Please select Quantity before adding items.

Oxytocin acetate 相关产品

bull;相关化合物库:

  • Covalent Screening Library Plus
  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • FDA-Approved Drug Library Mini
  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Metabolism/Protease Compound Library
  • FDA-Approved Drug Library
  • Human Endogenous Metabolite Compound Library
  • Drug Repurposing Compound Library
  • Covalent Screening Library
  • Macrocyclic Compound Library
  • Endocrinology Compound Library
  • Anti-COVID-19 Compound Library
  • Orally Active Compound Library
  • FDA Approved amp; Pharmacopeial Drug Library
  • Drug-Induced Liver Injury (DILI) Compound Library
  • Food-Sourced Compound Library
  • Rare Diseases Drug Library
  • Childrenrsquo;s Drug Library
  • Peptide Library

生物活性

Oxytocin acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma[1][2].

IC50 Target

Human Endogenous Metabolite

;

体内研究
(In Vivo)

During the LMA task, rat core body temperature are modestly decreased. Oxytocin acetate (subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose) produces significantly greater hypothermia (at 0.3 mg/kg) than either saline or the two lower doses of oxytocin. Oxytocin at 0.3 mg/kg produces a significantly greater decrease in temperature than vehicle between 15-60 min post injection, whereas 0.1 mg/kg slightly decreases temperature at the 30 min time point only[1].
Oxytocin acetate (0.1 mg/kg) engages in significantly more body sniffing and ano-genital sniffing compared with saline controls. It also increases the total time spent in social interaction (71.6±4.3 s), compared to those receiving vehicle (56.9±4.1 s)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fifty-six male Lister-hooded rats (150–200 g)[1]
Dosage: 0.1 mg/kg-0.3 mg/kg
Administration: Subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose
Result: Produced significantly greater hypothermia (at 0.3 mg/kg) than the saline group.

Clinical Trial

分子量

1067.24

Formula

C45H70N12O14S2
CAS 号

6233-83-6
Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge:Cys1-Cys6)
Sequence Shortening

CYIQNCPLG-NH2 (Disulfide bridge:Cys1-Cys6)
中文名称

醋酸催产素；醋酸缩宫素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 50 mg/mL (46.85 mM; Need ultrasonic)

DMSO : ≥ 44 mg/mL (41.23 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9370 mL 4.6850 mL 9.3700 mL
5 mM 0.1874 mL 0.9370 mL 1.8740 mL
10 mM 0.0937 mL 0.4685 mL 0.9370 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Shivali Kohli, et al. Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumben dopamine release in rats. Neuropsychopharmacology. 2019 Jan;44(2):295-305.

    [2]. C Sue Carter, et al. Is Oxytocin “Nature’s Medicine”? Pharmacol Rev. 2020 Oct;72(4):829-861.