Cyclosporin A-Derivative 1

发表于由

Cyclosporin A-Derivative 1;

Cyclosporin A-Derivative 1 是环孢菌素 A 衍生的结晶中间体，来自专利 WO 2013167703 A1。Cyclosporin A 是一种免疫抑制剂，能够与亲环蛋白结合并抑制钙调磷酸酶。

Cyclosporin A-Derivative 1amp;;

Cyclosporin A-Derivative 1 Chemical Structure

CAS No. : 1487360-85-9

规格 价格 是否有货
1 mg ￥1500 询问价格 货期
5 mg ￥3500 询问价格 货期

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Cyclosporin A-Derivative 1 的其他形式现货产品:

Cyclosporin A-Derivative 1 Free base

生物活性

Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

体外研究
(In Vitro)

Cyclosporin A-Derivative 1 is a non-immunosuppressive Cyclosporine A derivative. The cyclosporin is acylated on the butenyl-methyl-threonine side chain and then subjected to a ring-opening reaction (the ring opens between the sarcosine and the N-methyl-leucine residues). Cyclosporin A-Derivative 1 is a linear peptide intermediate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1364.50

Formula

C65H118BF4N11O14
CAS 号

1487360-85-9
Sequence

Leu-Val-Leu-Ala-{d-Ala}-Leu-Leu-Val-{Aaa}-{Abu}-{Sar}
Sequence Shortening

LVLA-{d-Ala}-LLV-{Aaa}-{Abu}-{Sar}
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Fabrice Gallou, et al. Process for the manufacture of cyclic undecapeptides. WO 2013167703 A1.