[Sar9] Substance P

发表于由

[Sar9] Substance P;

[Sar9] Substance P 是一种有效的选择性神经激肽 (NK)-1 受体激动剂。

[Sar9] Substance Pamp;;

[Sar9] Substance P Chemical Structure

CAS No. : 77128-75-7

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

[Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist[1].

IC50 Target

Neurokinin (NK)-1 receptor[1]
分子量

1361.66

Formula

C64H100N18O13S
CAS 号

77128-75-7
Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-{SAR}-Leu-Met-NH2
Sequence Shortening

RPKPQQFF-{SAR}-LM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Lieberman DN, et al. Substance P enhances NMDA channel function in hippocampal dentate gyrus granule cells. J Neurophysiol. 1998 Jul;80(1):113-9.