Leucokinin VIII(Synonyms: Leucokinin 8)

发表于由

Leucokinin VIII;(Synonyms: Leucokinin 8)

Leucokinin VIII 是一种利尿八肽，从蟑螂头部提取物中得到。

Leucokinin VIIIamp;;(Synonyms: Leucokinin 8)

Leucokinin VIII Chemical Structure

规格 价格 是否有货
1 mg ￥900 询问价格 货期
5 mg ￥1900 询问价格 货期
10 mg ￥2900 询问价格 货期

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生物活性

Leucokinin VIII is an diuretic octapeptide isolated form head extracts of the cockroach.

体外研究
(In Vitro)

Leucokinin VIII is an octapeptide, increases the rates of transepithelial NaC1, KC1 and water secretion, increases the Cl conductance of the epithelial shunt via a receptor located at the basolateral side of the epithelium[1]. Leucokinin VIII also activates Ca2+-dependent signal pathway in principal cells of Aedes aegyptiMalpighian tubules[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

872.92

Formula

C42H52N10O11
Sequence

Gly-Ala-Ser-Phe-Tyr-Ser-Trp-Gly-NH2
Sequence Shortening

GASFYSWG-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Pannabecker TL, et al. Regulation of epithelial shunt conductance by the peptide leucokinin. J Membr Biol. 1993 Feb;132(1):63-76.

    [2]. Yu MJ, et al. Leucokinin activates Ca(2+)-dependent signal pathway in principal cells of Aedes aegypti Malpighian tubules. Am J Physiol Renal Physiol. 2002 Sep;283(3):F499-508.