N-Acetyl-Ser-Asp-Lys-Pro;(Synonyms: Ac-SDKP)
N-Acetyl-Ser-Asp-Lys-Pro 是来自骨髓的内源性四肽,是 ACE 的N-末端位点的特异性底物。
N-Acetyl-Ser-Asp-Lys-Pro Chemical Structure
CAS No. : 127103-11-1
规格 | 是否有货 | ||
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100 mg | ; | 询价 | ; |
250 mg | ; | 询价 | ; |
500 mg | ; | 询价 | ; |
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N-Acetyl-Ser-Asp-Lys-Pro 的其他形式现货产品:
生物活性 |
N-Acetyl-Ser-Asp-Lys-Pro, an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE. |
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体外研究 (In Vitro) |
N-Acetyl-Ser-Asp-Lys-Pro is degraded specifically by ACE, and its plasma level rises substantially during ACE inhibitor therapy. Flow cytometry of rat cardiac fibroblasts treated with N-Acetyl-Ser-Asp-Lys-Pro shows significant inhibition of the progression of cells from G0/G1 phase to S phase of the cell cycle. Moreover, phosphorylation and nuclear translocation of Smad2 is decreased in cardiac fibroblasts treated with N-Acetyl-Ser-Asp-Lys-Pro[1]. N-acetyl-seryl-aspartyl-lysyl-proline appears to exert this function by blocking the action of a stem cell-specific proliferation stimulator and acts selectively on quiescent progenitors[2]. N-Acetyl-Ser-Asp-Lys-Pro inhibits collagenase expression and activation is associated with increased expression of TIMP-1 and TIMP-2. N-Acetyl-Ser-Asp-Lys-Pro normalizes the IL-1β-mediated increase in MMP-2 and MMP-9 activities and MMP-13 expression[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
体内研究 (In Vivo) |
N-Acetyl-Ser-Asp-Lys-Pro prevents hypertension-induced inflammatory cell infiltration, collagen deposition, nephrin downregulation and albuminuria, which could lead to renoprotection in hypertensive mice[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
487.50 |
Formula |
C20H33N5O9 |
CAS 号 |
127103-11-1 |
Sequence |
Ac-Ser-Asp-Lys-Pro |
Sequence Shortening |
Ac-SDKP |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
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