Dynorphin B (1-13)(Synonyms: 强啡肽 B (1-13))

发表于由

Dynorphin B (1-13);(Synonyms: 强啡肽 B (1-13))

Dynorphin B (1-13) 是一种阿片样 κ 受体 (κ-opioid receptor) 激动剂。

Dynorphin B (1-13)amp;;(Synonyms: 强啡肽 B (1-13))

Dynorphin B (1-13) Chemical Structure

CAS No. : 83335-41-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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Dynorphin B (1-13) 的其他形式现货产品:

Dynorphin B (1-13) (TFA)

生物活性

Dynorphin B (1-13) acts as an agonist on opioid κ-receptor.

IC50 Target

κ-opioid receptor[1]
体外研究
(In Vitro)

Dynorphin B (1-13), a 13 amino acid, is an extraordinarily potent opioid peptide. The neurophysiological actions of Dynorphin B (1-13) have been the subject of considerable research effort[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1570.84

Formula

C74H115N21O17
CAS 号

83335-41-5
Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr
Sequence Shortening

YGGFLRRQFKVVT
中文名称

强啡肽 B (1-13)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Chavkin C. Dynorphin–still an extraordinarily potent opioid peptide. Mol Pharmacol. 2013 Apr;83(4):729-36.