Xenopsin(Synonyms: 爪蟾肽)

Xenopsin;(Synonyms: 爪蟾肽) 纯度: 99.77%

Xenopsin 是一种来自非洲爪蟾皮肤的神经降压素样八肽。Xenopsin 抑制胃泌素刺激的胃酸分泌。

Xenopsinamp;;(Synonyms: 爪蟾肽)

Xenopsin Chemical Structure

CAS No. : 51827-01-1

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Xenopsin 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Xenopsin, a neurotensin-like octapeptide from Xenopus laevis skin[1]. Xenopsin is an inhibitor of Tetragastrin stimulated gastric acid secretion[2].

体外研究
(In Vitro)

Xenopsin is a biologically active octapeptide found in skin extracts from Xenopus laevis[1]. Xenopsin produces a significant inhibition of tetragastrin-stimulated gastric acid output[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

980.16

Formula

C47H73N13O10

CAS 号

51827-01-1

Sequence

{Glp}-Gly-Lys-Arg-Pro-Trp-Ile-Leu

Sequence Shortening

{Glp}-GKRPWIL

中文名称

爪蟾肽

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Sures I, et al. Xenopsin: the neurotensin-like octapeptide from Xenopus skin at the carboxyl terminus of its precursor. Proc Natl Acad Sci U S A. 1984 Jan;81(2):380-4.

    [2]. Zinner MJ, et al. Effect of xenopsin on blood flow, hormone release, and acid secretion. Am J Physiol. 1982 Sep;243(3):G195-9.