RGD peptide (GRGDNP)

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RGD peptide (GRGDNP);

RGD peptide (GRGDNP) 作为整合素-配体相互作用的抑制剂，在细胞黏附、迁移、生长和分化中发挥重要作用。RGD peptide (GRGDNP) 通过激活构象变化促进细胞凋亡，从而增强caspase-3的活化。

RGD peptide (GRGDNP)amp;;

RGD peptide (GRGDNP) Chemical Structure

CAS No. : 114681-65-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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RGD peptide (GRGDNP) 的其他形式现货产品:

RGD peptide (GRGDNP) (TFA)

生物活性

RGD peptide (GRGDNP) acts as an inhibitor of integrin-ligand interactions and plays an important role in cell adhesion, migration, growth, and differentiation[1]. RGD peptide (GRGDNP) promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing[2][3].

分子量

614.61

Formula

C23H38N10O10
CAS 号

114681-65-1
Sequence

Gly-Arg-Gly-Asp-Asn-Pro
Sequence Shortening

GRGDNP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Ruoslahti, E., and Öbrink, B. Common principles in cell adhesion Experimental Cell Research 227, 1-11 (1996).

    [2]. Meredith JE Jr, et al. Integrins, adhesion and apoptosis. Trends Cell Biol. 1997 Apr;7(4):146-50.

    [3]. Yang W, et al. Activation of the Cdc42-associated tyrosine kinase-2 (ACK-2) by cell adhesion via integrin beta1. J Biol Chem. 1999 Mar 26;274(13):8524-30.