Magainin 1(Synonyms: 蛙皮素 1 Magainin I)

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Magainin 1;(Synonyms: 蛙皮素 1; Magainin I)

Magainin 1 (Magainin I) 是从 Xenopus laevis 皮肤中分离出的一种抗菌和两亲性肽。Magainin 1 对多种革兰氏阴性和革兰氏阳性细菌均表现出抗生素活性。

Magainin 1amp;;(Synonyms: 蛙皮素 1; Magainin I)

Magainin 1 Chemical Structure

CAS No. : 108433-99-4

规格 价格 是否有货
500 μg ￥700 询问价格 货期
1 mg ￥1200 询问价格 货期
5 mg ￥4800 询问价格 货期
10 mg ￥8100 询问价格 货期

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生物活性

Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria[1][2][3].

体外研究
(In Vitro)

Magainin 1 interacts with acidic lipids through electrostatic interactions followed by hydrophobic interactions to form an amphiphilic helix, inducing the leakage. Magainin 1 induces the leakage of calcein specifically out of negatively-charged vesicles. The peptide binds to bovine brain phosphatidylserine sonicated vesicles according to the Langmuir isotherm with a binding constant of 3.8×105 M-1 and a binding-site number of 0.10 per lipid molecule[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2409.85

Formula

C112H177N29O28S
CAS 号

108433-99-4
Sequence

Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Gly-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Lys-Ser
Sequence Shortening

GIGKFLHSAGKFGKAFVGEIMKS
中文名称

蛙皮素 1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Duclohier H, et al. Antimicrobial peptide magainin I from Xenopus skin forms anion-permeable channels in planar lipid bilayers. Biophys J. 1989 Nov;56(5):1017-21.

    [2]. Matsuzaki K, et al. Magainin 1-induced leakage of entrapped calcein out of negatively-charged lipid vesicles. Biochim Biophys Acta. 1989 May 19;981(1):130-4.

    [3]. Zasloff M, et al. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53.