PGLa

PGLa;

PGLa 是一种含 21 个残基的抗菌肽。PGLa 是在蛙皮及其分泌物中发现的抗菌肽麦角菌素家族的成员。

PGLaamp;;

PGLa Chemical Structure

CAS No. : 102068-15-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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PGLa 的其他形式现货产品:

PGLa TFA

生物活性

PGLa, a 21-residue peptide, is an antimicrobial peptide. PGLa is a member of the magainin family of antibiotic peptides found in frog skin and its secretions[1].

IC50 Target

Anti-bacteria[1]

体外研究
(In Vitro)

PGLa is a peptide starting with a glycine and ending with a leucine amide[1].
PGLa is bacteriostatic against both Gram-positive and Gram-negative bacteria with MIC values of 64 and 32 mg/L against S. aureus and E. coli, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

1968.45

Formula

C88H162N26O22S

CAS 号

102068-15-5

Sequence

Gly-Met-Ala-Ser-Lys-Ala-Gly-Ala-Ile-Ala-Gly-Lys-Ile-Ala-Lys-Val-Ala-Leu-Lys-Ala-Leu-NH2

Sequence Shortening

GMASKAGAIAGKIAKVALKAL-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Bechinger B, et al. Structure and dynamics of the antibiotic peptide PGLa in membranes by solution and solid-state nuclear magnetic resonance spectroscopy. Biophys J. 1998 Feb;74(2 Pt 1):981-7.

    [2]. Radchenko DS, et al. Does a methionine-to-norleucine substitution in PGLa influence peptide-membrane interactions? Biochim Biophys Acta. 2016 Sep;1858(9):2019-27.