JMV 449

JMV 449;

JMV 449 是一种有效的神经降压素受体 (neurotensin receptor) 激动剂。JMV 449 显示抑制 [125I]-neurotensin 与新生小鼠脑结合的 IC50 为 0.15 nM,对收缩豚鼠回肠的 EC50 为 1.9 nM。JMV 449 对小鼠具有高效、持久的降温和缓解疼痛作用。

JMV 449amp;;

JMV 449 Chemical Structure

CAS No. : 139026-66-7

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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JMV 449 的其他形式现货产品:

JMV 449 acetate

生物活性

JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC50 of 0.15 nM for inhibition of [125I]-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse[1][2].

体内研究
(In Vivo)

JMV 449 (120 pmol/mouse; i.c.v) shows analgesic effect[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss albino mice[2]
Dosage: 120 pmol/mouse
Administration: i.c.v.
Result: Showed dose-response relation-ships for the analgesic effect.

分子量

746.98

Formula

C38H66N8O7

CAS 号

139026-66-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Lugrin D, et al. Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur J Pharmacol. 1991;205(2):191-198.

    [2]. Dubuc I, et al JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur J Pharmacol. 1992;219(2):327-329.