Nociceptin(1-7)

Nociceptin(1-7);

Nociceptin(1-7) 是 Nociceptin (HY-P0183) 的 N 端生物活性片段。Nociceptin(1-7) 是一种有效的 ORL1 (NOP) 受体激动剂,具有缓解疼痛活性。Nociceptin (1-7) 联合 Nociceptin 可降低体内对痛觉的敏感。

Nociceptin(1-7)amp;;

Nociceptin(1-7) Chemical Structure

CAS No. : 178249-42-8

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo[1].

体内研究
(In Vivo)

Nociceptin (1-7) (intrathecal injection; 150–1200  nmol; single dose) has no significant effect in the nociceptive thermal threshold (hyperalgesia). However, when nociceptin (1–7) is injected simultaneously with nociceptin (3.0 fmol), nociceptin-induced hyperalgesia is significantly reduced[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 150–1200  nmol
Administration: Intrathecal injection; single dose
Result: Co-treatment with nociceptin could reduce hyperalgesia.

分子量

655.70

Formula

C31H41N7O9

CAS 号

178249-42-8

Sequence Shortening

FGGFTGA

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. T Sakurada, et al. Nociceptin (1 – 7) antagonizes nociceptin-induced hyperalgesia in mice.Br J Pharmacol. 1999 Nov;128(5):941-4.