Cortistatin 14, human, rat(Synonyms: CST-14, human, rat)

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Cortistatin 14, human, rat;(Synonyms: CST-14, human, rat)

Cortistatin 14, human, rat (CST-14, human, rat) 是一种具有神经抑制和睡眠调节特性的神经肽，能与 5 种克隆生长抑素受体 (SSTRs) 和生长激素释放肽受体结合，发挥其生物学活性，并与大脑皮层和海马内的 GABA 共存。

Cortistatin 14, human, ratamp;;(Synonyms: CST-14, human, rat)

Cortistatin 14, human, rat Chemical Structure

CAS No. : 193829-96-8

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生物活性

Cortistatin 14, human, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus[1][2].

分子量

1721.01

Formula

C81H113N19O19S2
CAS 号

193829-96-8
Sequence

Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys (Disulfide bridge: Cys2-Cys13)
Sequence Shortening

PCKNFFWKTFSSCK (Disulfide bridge: Cys2-Cys13)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jiang J, et al. Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via MediatingGhrelin and GABAA Receptor Signaling Pathway. Front Pharmacol. 2018 Jul 19;9:767.

    [2]. de Lecea L, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996 May 16;381(6579):242-5.