MM-401

MM-401;

MM-401 有效抑制 MLL1-WDR5 相互作用,IC50 为 0.9 nM。 MM-401 对 WDR5 具有高结合亲和力 (Ki<1 nM)。 MM-401 特异性抑制 MLL1 H3 赖氨酸 (K) 4 甲基转移酶活性,但不影响其他 MLL 家族组蛋白甲基转移酶 (HMT)。 MM-401可用于MLL白血病的研究。

MM-401amp;;

MM-401 Chemical Structure

CAS No. : 1442106-10-6

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生物活性

MM-401 is a potent inhibitor for the MLL1-WDR5 interaction with the IC50 of 0.9 nM in disrupting WDR5-MLL1 interaction. MM-401 maintains high binding affinity to WDR5 (Ki<1 nm). mm-401 specifically inhibits mll1 h3 lysine (k) 4 methyltransferase activity but does not affect other mll family histone methyltransferases (hmts). can be used for the research of leukemia[1].

分子量

586.73

Formula

C29H46N8O5

CAS 号

1442106-10-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Fang Cao, et al. Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia. Mol Cell. 2014 Jan 23;53(2):247-61.