MM-401;
MM-401 有效抑制 MLL1-WDR5 相互作用,IC50 为 0.9 nM。 MM-401 对 WDR5 具有高结合亲和力 (Ki<1 nM)。 MM-401 特异性抑制 MLL1 H3 赖氨酸 (K) 4 甲基转移酶活性,但不影响其他 MLL 家族组蛋白甲基转移酶 (HMT)。 MM-401可用于MLL白血病的研究。
MM-401 Chemical Structure
CAS No. : 1442106-10-6
规格 | 是否有货 | ||
---|---|---|---|
100 mg | ; | 询价 | ; |
250 mg | ; | 询价 | ; |
500 mg | ; | 询价 | ; |
* Please select Quantity before adding items.
生物活性 |
MM-401 is a potent inhibitor for the MLL1-WDR5 interaction with the IC50 of 0.9 nM in disrupting WDR5-MLL1 interaction. MM-401 maintains high binding affinity to WDR5 (Ki<1 nm). mm-401 specifically inhibits mll1 h3 lysine (k) 4 methyltransferase activity but does not affect other mll family histone methyltransferases (hmts). can be used for the research of leukemia[1]. |
---|---|
分子量 |
586.73 |
Formula |
C29H46N8O5 |
CAS 号 |
1442106-10-6 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
|