AP 811

发表于2023年10月11日由Whatman官网

AP 811;

AP 811 是一种选择性心钠素清除受体 (APN-CR, NPR3) 拮抗剂 (K_i=0.48 nM)。AP 811 对NPR3的选择性是NPR1的 20000 多倍。AP 811消除了 ANP 诱导的泵刺激。

AP 811amp;;

AP 811 Chemical Structure

CAS No. : 124833-45-0

规格		是否有货
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生物活性	AP 811 is a selective atrial natriuretic peptide clearance receptor (APN-CR, NPR3) antagonist (K_i=0.48 nM). AP 811 displays >20,000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation^[1]^[2].
分子量	915.09
Formula	C₄₆H₆₆N₁₂O₈
CAS 号	124833-45-0
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Veale CA, et al. The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg Med Chem Lett. 2000;10(17):1949-1952. [2]. William M, et al. Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation. Am J Physiol Cell Physiol. 2008;294(4):C1067-C1073.