Argireline acetate(Synonyms: Acetyl hexapeptide-3 acetate)

Argireline acetate;(Synonyms: Acetyl hexapeptide-3 acetate)

Argireline acetate (Acetyl hexapeptide-3 acetate) 是一种无毒,可渗透皮肤的抗皱肽。Argireline acetate 可显着抑制神经肌肉接头处依赖 Ca2+ 的神经递质释放。Argireline acetate 具有抗皱和抗衰老的作用。

Argireline acetateamp;;(Synonyms: Acetyl hexapeptide-3 acetate)

Argireline acetate Chemical Structure

规格 是否有货
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Argireline acetate 的其他形式现货产品:

Argireline

生物活性

Argireline acetate (Acetyl hexapeptide-3 acetate) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline acetate significantly inhibits Ca2+ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline acetate has antiwrinkle and anti-aging activity[1][2][3].

体外研究
(In Vitro)

The incubation of Argireline solution in different concentrations with human embryonic kidney HEK-293 (IC50 of 34.862 μM) and neuroblastoma IMR-32 cells (IC50 of 68.458 μM)) for 48 h have dose dependent antiproliferative effect. Argireline solution incubated in different concentrations with HSF has a dose-dependent antiproliferative effect on those cells. Cellular proliferation is not effected in Argireline low concentration[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Argireline is applied to the aged mice twice daily for 6 weeks. There is an improvement in the histological structure of skin tissue in the aged mice; the amount of type I collagen fibers increased, while that of type III collagen fibers decreased. Argireline could improve the histological structure of skin tissue and rejuvenate the aging skin[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

949.04

Formula

C36H64N14O14S

Sequence

N-acetyl-Glu-Glu-Met-Gln-Arg-Arg-NH2

Sequence Shortening

Ac-EEMQRR-NH2

中文名称

醋酸阿基瑞林

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Blanes-Mira C, et al. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002 Oct;24(5):303-10.

    [2]. Grosicki M, et al. The study of cellular cytotoxicity of argireline – an anti-aging peptide. Acta Biochim Pol. 2014;61(1):29-32.

    [3]. Wang Y, et al. The anti-wrinkle efficacy of Argireline. J Cosmet Laser Ther. 2013 Aug;15(4):237-41.