Orphan GPCR SP9155 agonist P550 (mouse, rat)(Synonyms: 26RFa (mouse, rat))

Orphan GPCR SP9155 agonist P550 (mouse, rat);(Synonyms: 26RFa (mouse, rat))

Orphan GPCR SP9155 agonist P550 (mouse, rat) (26RFa (mouse, rat)),RFamide 肽家族的成员,具有促食欲作用,是小鼠孤儿受体 GPR103 的同源配体,也命名为 SP9155 或 AQ27。

Orphan GPCR SP9155 agonist P550 (mouse, rat)amp;;(Synonyms: 26RFa (mouse, rat))

Orphan GPCR SP9155 agonist P550 (mouse, rat) Chemical Structure

CAS No. : 600171-70-8

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生物活性

Orphan GPCR SP9155 agonist P550 (mouse, rat) (26RFa (mouse, rat)), a member of the RFamide peptide family with orexigenic effect, is the cognate ligand of the mouse orphan receptor GPR103, also designated SP9155 or AQ27[1][2].

体外研究
(In Vitro)

26RFa is a key neuropeptide in the regulation of energy metabolism[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

26RFa dose-dependently reduces glucose-induced insulin release, inhibits the insulin responses to both arginine and exendin-4 and did not affect glucagon output in rat pancreas[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2820.17

Formula

C126H195N37O37

CAS 号

600171-70-8

Sequence

Ala-Ser-Gly-Pro-Leu-Gly-Thr-Leu-Ala-Glu-Glu-Leu-Ser-Ser-Tyr-Ser-Arg-Arg-Lys-Gly-Gly-Phe-Ser-Phe-Arg-Phe-NH2

Sequence Shortening

ASGPLGTLAEELSSYSRRKGGFSFRF-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Chartrel N, et al. Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. Proc Natl Acad Sci U S A. 2003;100(25):15247-15252.

    [2]. Chartrel N, et al. The Neuropeptide 26RFa (QRFP) and Its Role in the Regulation of Energy Homeostasis: A Mini-Review. Front Neurosci. 2016;10:549. Published 2016 Nov 29.

    [3]. Egido EM, et al. 26RFa, a novel orexigenic neuropeptide, inhibits insulin secretion in the rat pancreas. Peptides. 2007;28(4):725-730.