PAMP-12

发表于2023年10月12日由Whatman官网

PAMP-12;

PAMP-12 是一种有效的 MRGPRX2 (MrgX2) 激动剂 (EC₅₀=20-50 nM)。PAMP-12 是一种内源性肽，通过抑制交感神经末梢和肾上腺嗜铬细胞的儿茶酚胺分泌引起低血压。

PAMP-12amp;;

PAMP-12 Chemical Structure

CAS No. : 929905-12-4

规格		是否有货
100 mg	;	询价	;
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生物活性	PAMP-12 is a potent MRGPRX2 (MrgX2) agonist (EC₅₀=20-50 nM). PAMP-12 is an endogenous peptide that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells^[1].
分子量	1619.91
Formula	C₇₇H₁₁₈N₂₄O₁₅
CAS 号	929905-12-4
Sequence Shortening	FRKKWNKWALSR
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Kamohara M, et al. Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem Biophys Res Commun. 2005;330(4):1146-1152. [2]. Chen E, et al. Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target. Gastroenterology. 2021;160(5):1709-1724.