TAT-P4-(DATC5)2 TFA

发表于由

TAT-P4-(DATC5)2 TFA;

TAT-P4-(DATC5)2 TFA 是一种蛋白激酶 C 相互作用蛋白 1 PDZ 结构域 (PICK1 PDZ domain) 的高亲和力多肽抑制剂，其 Ki 值为 1.7 nM。TAT-P4-(DATC5)2 TFA 能抑制大鼠可卡因上瘾。

TAT-P4-(DATC5)2 TFAamp;;

TAT-P4-(DATC5)2 TFA Chemical Structure

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生物活性

TAT-P4-(DATC5)2 TFA is a high-affinity peptide inhibitor of the PICK1 (protein interacting with C kinase-1) PDZ domain, with a Ki of 1.7 nM. TAT-P4-(DATC5)2 TFA attenuats the reinstatement of cocaine seeking in rats[1].

IC50 Target

Ki: 1.7 nM (PICK1 PDZ domain)[1]
体内研究
(In Vivo)

TAT-P4-(DATC5)2 TFA (0.99 μg/kg, 9.9 μg/kg; Infused intravenously) dose-dependently attenuats the reinstatement of cocaine seeking in rats at doses that do not produce operant learning deficits or suppress locomotor activity [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-300 g) [1]
Dosage: 0.99 μg/kg, 9.9 μg/kg
Administration: Infused intravenously, 45 min prior to an acute injection of cocaine (10 mg/kg, i.p.)
Result: Attenuated the reinstatement of cocaine seeking in rats.

分子量

3403.97

Formula

C16H25F3O8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Christopher Turner, et al. Administration of a Novel High Affinity PICK1 PDZ Domain Inhibitor Attenuates Cocaine Seeking in Rats. Neuropharmacology. 2020 Mar 1;164:107901.