Cyclosporin D

Cyclosporin D;

Cyclosporin D 是 Cyclosporin A 的代谢产物,是一种弱免疫抑制剂。Cyclosporin D 作为 Cyclosporin A 定量的内标,Cyclosporin A 是一种免疫抑制药物,通过抑制钙调磷酸酶和钙调磷酸酶依赖性转录因子激活的T细胞核因子 (NFAc) 来抑制 T 细胞活化。

Cyclosporin Damp;;

Cyclosporin D Chemical Structure

CAS No. : 63775-96-2

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Cyclosporin D 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Natural Product Library
  • Macrocyclic Compound Library
  • Microbial Metabolite Library
  • Peptide Library

生物活性

Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A[1][2]. Cyclosporin A is a potent immunosuppressant drug, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc)[3].

体外研究
(In Vitro)

Cyclosporine D inhibits Ca2+/calmodulin dependent EF-2 phosphorylation in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Cyclosporine D is a potent inhibitor in vivo of phorbol ester TPA-induced biological effects in mouse skin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1216.64

Formula

C63H113N11O12

CAS 号

63775-96-2

Sequence

cyclo ({Aaa}-Val-{Sar}-Leu-Val-Leu-Ala-Ala-Leu-Leu-{d-Val})

Sequence Shortening

cyclo ({Aaa}-V-{Sar}-LVLAALL-{d-Val})

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献
  • [1]. Gschwendt M, et al. The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. Biochem Biophys Res Commun. 1988 Jan 29;150(2):545-51.

    [2]. Kaiser P, et al. A new approach for the determination of immunosuppressive drugs using HPLC-MS/MS and Cs+ adducts. Ger Med Sci. 2006 Jan 18;4:Doc01.

    [3]. Minguillón J, et al. Concentrations of cyclosporin A and FK506 that inhibit IL-2 induction in human T cells do not affect TGF-beta1 biosynthesis, whereas higher doses of cyclosporin A trigger apoptosis and release of preformed TGF-beta1. J Leukoc Biol. 2005 May;77(5):748-58. Epub 2005 Feb 16.