Cyclosporin D;
Cyclosporin D 是 Cyclosporin A 的代谢产物,是一种弱免疫抑制剂。Cyclosporin D 作为 Cyclosporin A 定量的内标,Cyclosporin A 是一种免疫抑制药物,通过抑制钙调磷酸酶和钙调磷酸酶依赖性转录因子激活的T细胞核因子 (NFAc) 来抑制 T 细胞活化。
Cyclosporin D Chemical Structure
CAS No. : 63775-96-2
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5 mg | ¥2300 | In-stock | |
10 mg | ¥3700 | In-stock | |
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Cyclosporin D 相关产品
bull;相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Immunology/Inflammation Compound Library
- Natural Product Library
- Macrocyclic Compound Library
- Microbial Metabolite Library
- Peptide Library
生物活性 |
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A[1][2]. Cyclosporin A is a potent immunosuppressant drug, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc)[3]. |
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体外研究 (In Vitro) |
Cyclosporine D inhibits Ca2+/calmodulin dependent EF-2 phosphorylation in vitro[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Cyclosporine D is a potent inhibitor in vivo of phorbol ester TPA-induced biological effects in mouse skin[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
1216.64 |
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Formula |
C63H113N11O12 |
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CAS 号 |
63775-96-2 |
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Sequence |
cyclo ({Aaa}-Val-{Sar}-Leu-Val-Leu-Ala-Ala-Leu-Leu-{d-Val}) |
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Sequence Shortening |
cyclo ({Aaa}-V-{Sar}-LVLAALL-{d-Val}) |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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参考文献 |
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