AC 187;
AC 187 是一种有效且具有口服活性的胰淀素受体 (amylin receptor) 拮抗剂,IC50 为 0.48 nM,Ki 为 0.275 nM。AC 187 对胰淀素受体的选择性高于降钙素和 CGRP 受体。AC 187 具有神经保护作用。
AC 187 Chemical Structure
CAS No. : 151804-77-2
规格 | 是否有货 | ||
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100 mg | ; | 询价 | ; |
250 mg | ; | 询价 | ; |
500 mg | ; | 询价 | ; |
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AC 187 的其他形式现货产品:
生物活性 |
AC 187 is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 has neuroprotective effects[1][2]. |
IC50 Target |
IC50: 0.48 nM (amylin receptor) |
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体外研究 (In Vitro) |
AC 187 blocks amyloidβ protein (Aβ)-induced neurotoxicity. Treatment of cultures with AC 187 before exposure to Aβ results in significantly improved neuronal survival[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
体内研究 (In Vivo) |
AC 187 (30 mg/mL) increases glucagon concentration, accelerates gastric emptying of liquids, and results in an exaggerated post-challenge glycemia in hyperinsulinemic clamps in Sprague-Dawley (HSD) rats[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
2890.25 |
Formula |
C127H205N37O40 |
CAS 号 |
151804-77-2 |
Sequence |
Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2 |
Sequence Shortening |
Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH2 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
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