Ac-Ile-Glu-Thr-Asp-pNA

Ac-Ile-Glu-Thr-Asp-pNA;

Ac-Ile-Glu-Thr-Asp-pNA 是 caspase-8 的底物。Caspase-8 结合并裂解Ile-Glu-Thr-Asp (IETD) 肽序列,释放对硝基苯胺,可通过 405 nm 处的比色检测来定量检测酶活性。

Ac-Ile-Glu-Thr-Asp-pNAamp;;

Ac-Ile-Glu-Thr-Asp-pNA Chemical Structure

CAS No. : 219138-21-3

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity[1].

分子量

638.62

Formula

C27H38N6O12

CAS 号

219138-21-3

Sequence Shortening

Ac-IETD-pNA

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Smith GK, et al. Expression, preparation, and high-throughput screening of caspase-8: discovery of redox-based and steroid diacid inhibition. Arch Biochem Biophys. 2002;399(2):195-205.