MDP1 acetate

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MDP1 acetate;

MDP1 acetate 是一种蜂毒肽 (melittin) 衍生肽，可改变革兰氏阳性和革兰氏阴性细菌膜的完整性，并通过膜损伤杀死细菌。MDP1 acetate 对金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌的耐多药 (MDR) 和参考菌株具有很高的抗菌活性。

MDP1 acetateamp;;

MDP1 acetate Chemical Structure

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生物活性

MDP1 acetate, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 acetate has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa[1].

体外研究
(In Vitro)

MDP1 acetate exhibits more potent antibacterial activities against S. aureus, E. coli and P. aeruginosa.
Geometric means of MICs for MDP1 is recorded at 4.06 μg/mL (S. aureus), 1.22 μg/mL (E. coli) and 3.75 μg/mL (P. aeruginosa), respectively[1].
DNA and calcein release and flow cytometry assays indicate a time-dependent antibacterial activity on the examined bacteria affected by MDP1 (10, 5, 2.5, 1.25, 0.625 and 0.312 μg/mL) acetate. Finally, SEM analyses highlights dose- and time-dependent effects of MDP1 acetate on S. aureus and E. coli bacteria by induction of vesicle or pore formation as well as cell lysis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2521.05

Formula

C113H206N34O30
Sequence Shortening

GIGAVLKVLTTGLPALIKRKRQQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Akbari R, et al. Action mechanism of melittin-derived antimicrobial peptides, MDP1 and MDP2, de novo designed against multidrug resistant bacteria. Amino Acids. 2018;50(9):1231-1243.