Norleual

Norleual;

Norleual 是一种血管紧张素 (Ang) IV 类似物,是一种肝细胞生长因子 (HGF)/c-Met 抑制剂,IC50 为 3 pM。Norleual 还是一种 AT4 拮抗剂,具有强大的抗血管生成活性。

Norleualamp;;

Norleual Chemical Structure

CAS No. : 334994-34-2

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生物活性

Norleual, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual is an AT4 receptor antagonist and exhibits potent antiangiogenic activities[1].

体外研究
(In Vitro)

Norleual at 20 and 50 pM significantly reduces HGF-dependent c-Met and Gab1 phosphorylation. 20 pM Norleual dramatically reduces HGF-initiated association between Gab1 and c-Met in HEK293 cells. Norleual markedly attenuates HGF-dependent c-Met activation and downstream signaling[1]. Norleual (1 pM-1 μM; 4 days) is able to inhibit HGF-dependent signaling, proliferation, migration, and invasion in multiple cell types at concentrations in the picomolar range in MDCK cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Norleual (50 μg/kg; intraperitoneal injection; daily; for 2 weeks; C57BL/6 mice) suppresses pulmonary colonization by B16-F10 murine melanoma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

774.95

Formula

C41H58N8O7

CAS 号

334994-34-2

Sequence Shortening

{Nle}-Y-{Leu-(CH2-NH2)}-HPF

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. B J Yamamoto, et al. The angiotensin IV analog Nle-Tyr-Leu-psi-(CH2-NH2)3-4-His-Pro-Phe (norleual) can act as a hepatocyte growth factor/c-Met inhibitor. J Pharmacol Exp Ther. 2010 Apr;333(1):161-73.