Temporin A

Temporin A;

Temporin A 是从 Rana temporaria 皮肤中分离得到的一种短α螺旋抗菌肽。Temporin A 对广谱革兰氏阳性菌有效。Temporin A 直接与微生物的细胞膜相互作用,在抗菌浓度下对红细胞无毒。Temporin A 还具有抗真菌活性,可对抗酵母样白色念珠菌。

Temporin Aamp;;

Temporin A Chemical Structure

CAS No. : 188713-69-1

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生物活性

Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans)[1][1][3].

体外研究
(In Vitro)

Temporin A (TA) is a small, basic, highly hydrophobic, antimicrobial peptide amide (FLPLIGRVLSGIL-NH2) found in the skin of the European red frog, Rana temporaria. It has variable antibiotic activities against a broad spectrum of microorganisms, including clinically important Methicillin-sensitive and -resistant Staphylococcus aureus as well as Vancomycin-resistant Enterococcus faecium strains[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1396.76

Formula

C68H117N17O14

CAS 号

188713-69-1

Sequence Shortening

FLPLIGRVLSGIL-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Mäntylä T, Sirola H, Kansanen E, et al. Effect of temporin A modifications on its cytotoxicity and antimicrobial activity. APMIS. 2005;113(7-8):497-505.

    [2]. Wade D, et al. Antibacterial activities of temporin A analogs. FEBS Lett. 2000;479(1-2):6-9.

    [3]. Kamysz W, et al. Temporin A and its retro-analogues: synthesis, conformational analysis and antimicrobial activities. J Pept Sci. 2006;12(8):533-537.