Glucagon (1-29), bovine, human, porcine hydrochloride(Synonyms: 盐酸胰高血糖素 Porcine glucagon hydrochloride)

发表于由

Glucagon (1-29), bovine, human, porcine hydrochloride;(Synonyms: 盐酸胰高血糖素; Porcine glucagon hydrochloride)

Glucagon (1-29), bovine, human, porcine hydrochloride 是由胰腺 α 细胞产生的一种多肽激素。Glucagon (1-29), bovine, human, porcine hydrochloride 促进糖异生。Glucagon (1-29), bovine, human, porcine hydrochloride 可激活 HNF4α 并促进 HNF4α 磷酸化。

Glucagon (1-29), bovine, human, porcine hydrochlorideamp;;(Synonyms: 盐酸胰高血糖素; Porcine glucagon hydrochloride)

Glucagon (1-29), bovine, human, porcine hydrochloride Chemical Structure

CAS No. : 28270-04-4

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生物活性

Glucagon (1-29), bovine, human, porcine hydrochloride is a peptide hormone, produced by pancreatic α-cells. Glucagon hydrochloride stimulates gluconeogenesis[1]. Glucagon (1-29), bovine, human, porcine hydrochloride activates HNF4α and increases HNF4α phosphorylation[2][3].

体外研究
(In Vitro)

Upon binding to its receptor Gcgr, Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia[1].
Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis[1].
Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes[3].
Glucagon (100 nM) increases phosphorylayion of HNF4α[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[3]

Cell Line: Human primary hepatocytes (H1211, HH1215)
Concentration: 100 nM
Incubation Time:
Result: Resulted in a marked increase in the amount of phosphorylated HNF4α.

体内研究
(In Vivo)

Low-dose (20 μg/kg) Glucagon increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (12- to 24-week-old)[4]
Dosage: 20 μg/kg and 1 mg/kg
Administration: Administered by i.p. injection; 45 minutes
Result: Low-dose (20 μg/kg) increased glycemia and did not stimulate insulin secretion.
High-dose (1 mg/kg) lowered glycemia and stimulated insulin secretion.

分子量

3519.21

Formula

ClH
CAS 号

28270-04-4
Sequence

His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
Sequence Shortening

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
中文名称

盐酸胰高血糖素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Song WJ, et al. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab. 2014 Apr 1;19(4):667-81.

    [2]. Hirota K, et al. Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor. J Biol Chem. 2003 Apr 11;278(15):13056-60.

    [3]. Song KH, et al. Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in humanhepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis. Hepatology. 2006 Jan;43(1):117-25.

    [4]. Capozzi ME, et al. Glucagon lowers glycemia when β-cells are active. JCI Insight. 2019 Jul 23;5. pii: 129954.