Ac-RYYRWK-NH2

发表于2023年10月18日由Whatman官网

Ac-RYYRWK-NH2;

Ac-RYYRWK-NH2 是一个有效的和选择性 nociceptin receptor (NOP) 部分激动剂。[³H]Ac-RYYRWK-NH2 结合鼠皮层膜的 K_d 为0.071 nM，但是对 µ-,κ- 或 δ 阿片受体没有亲和力。

Ac-RYYRWK-NH2amp;;

Ac-RYYRWK-NH2 Chemical Structure

CAS No. : 200959-47-3

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生物活性	Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [³H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a K_d of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors^[1].
IC₅₀ Target	Kd: 0.071 nM (ORL1 in rat cortical membranes)^[1]
分子量	1012.17
Formula	C₂H₅KNOWY₂
CAS 号	200959-47-3
Sequence Shortening	Ac-RYYRWK-NH2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.J Pharmacol Exp Ther. 1997 Nov;283(2):735-41. [2]. M Ho, et al, Characterization of the ORL(1) receptor on adrenergic nerves in the rat anococcygeus muscle. Br J Pharmacol. 2000 Sep;131(2):349-55.