[Ala11,D-Leu15]-Orexin B(human)

[Ala11,D-Leu15]-Orexin B(human);

[Ala11,D-Leu15]-Orexin B(human) 是一种有效的,选择性的 orexin-2 receptor (OX2) 的激动剂。[Ala11,D-Leu15]-Orexin B(human) 对 OX2 (EC50=0.13 nM) 比对 OX1 (52 nM) 高出 400 倍的选择性。

[Ala11,D-Leu15]-Orexin B(human)amp;;

[Ala11,D-Leu15]-Orexin B(human) Chemical Structure

CAS No. : 532932-99-3

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生物活性

[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (52 nM)[1].

IC50 Target[1]

OX2

0.13 nM (EC50)

OX1

52 nM (EC50)

分子量

2857.26

Formula

C120H206N44O35S

CAS 号

532932-99-3

Sequence

Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

Sequence Shortening

RSGPPGLQGRAQRLLQASGNHAAGILTM-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Asahi S, et al. Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B. Bioorg Med Chem Lett. 2003;13(1):111-113.