Huwentoxin XVI

Huwentoxin XVI;

Huwentoxin XVI,一种来自鸟蛛 Ornithoctonus huwena 的止痛剂,一种高度可逆和选择性的哺乳动物 N 型钙通道 (N-type calcium channel) (IC50 约为 60 nM) 拮抗剂。Huwentoxin XVI 对电压门控的 T 型钙通道,钾通道或钠通道没有影响。

Huwentoxin XVIamp;;

Huwentoxin XVI Chemical Structure

CAS No. : 1600543-88-1

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生物活性

Huwentoxin XVI, an analgesic, is a highly reversible and selective mammalian N-type calcium channel (IC50 of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI has no effect on voltagegated T-type calcium channels, potassium channels or sodium channels[1].

IC50 Target

IC50: ~60 nM (N-type calcium channel)[1]

分子量

4437.13

Formula

C196H292N50O56S6

CAS 号

1600543-88-1

Sequence

Cys-Ile-Gly-Glu-Gly-Val-Pro-Cys-Asp-Glu-Asn-Asp-Pro-Arg-Cys-Cys-Ser-Gly-Leu-Val-Cys-Leu-Lys-Pro-Thr-Leu-His-Gly-Ile-Trp-Tyr-Lys-Ser-Tyr-Tyr-Cys-Tyr-Lys-Lys (Disulfide bridge:Cys1-Cys16;Cys8-Cys21;Cys15-Cys36)

Sequence Shortening

CIGEGVPCDENDPRCCSGLVCLKPTLHGIWYKSYYCYKK (Disulfide bridge:Cys1-Cys16;Cys8-Cys21;Cys15-Cys36)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Meichun Deng, et al. Huwentoxin-XVI, an analgesic, highly reversible mammalian N-type calcium channel antagonist from Chinese tarantula Ornithoctonus huwena. Neuropharmacology. 2014 Apr;79:657-67.

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