Cyclic MKEY

发表于2023年10月30日由Whatman官网

Cyclic MKEY;

Cyclic MKEY 是 CXCL4-CCL5 异二聚体形成的合成环肽抑制剂，其通过介导炎症来防止动脉粥样硬化和主动脉瘤形成。Cyclic MKEY 还可以预防小鼠中风引起的脑损伤。

Cyclic MKEYamp;;

Cyclic MKEY Chemical Structure

CAS No. : 934385-55-4

规格		是否有货
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生物活性	Cyclic MKEY is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY also protects against stroke-induced brain injury in mice^[1]^[2].
IC₅₀ Target	CXCL4-CCL5 heterodimer formation^[1]
分子量	2532.89
Formula	C₁₁₃H₁₇₄N₂₈O₃₄S₂
CAS 号	934385-55-4
Sequence Shortening	CKEYFYTSSKSSNLAVVFVTRC
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Fan Y,et al. MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice. J Am Heart Assoc. 2016 Sep 15;5(9). pii: e003615. [2]. Iida Y, et al. Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits experimental aortic aneurysm initiation and progression. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):718-26.