Sarafotoxin S6a TFA

发表于由

Sarafotoxin S6a TFA;

Sarafotoxin S6a TFA 是一种 Sarafotoxin 类似物，是一种内皮素受体 (endothelin receptor ) 激动剂，具有与 Endothelin-3 (HY-P0204) 相似的 ETA/ETB 选择性。Sarafotoxin S6a TFA 诱导猪冠状动脉的 EC50 值为 7.5 nM。

Sarafotoxin S6a TFAamp;;

Sarafotoxin S6a TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Sarafotoxin S6a TFA , a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a TFA elicits the pig coronary artery with an EC50 value of 7.5 nM[1].

IC50 Target[1]

ETB

;

ETA

;

体外研究
(In Vitro)

Sarafotoxin S6a TFA is a rather weak agonist effect in guinea-pig aorta, the eliting concentration (EC50) is 150 nM in guinea-pig aorta.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2628.87

Formula

C107H157F3N28O36S5
Sequence

Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bridge:Cys1-Cys15;Cys3-Cys11)
Sequence Shortening

CSCKDMTDKECLNFCHQDVIW (Disulfide bridge:Cys1-Cys15;Cys3-Cys11)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vivo:
  • 1.

    S6a is dissolved in 0.1% aqueous acetic acid and diluted in 0.9% NaCl[1].

参考文献

  • [1]. P Schoeffter, et al. Differences between endothelin receptors mediating contraction of guinea-pig aorta and pig coronary artery. Eur J Pharmacol