Human PD-L1 inhibitor V

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Human PD-L1 inhibitor V;

Human PD-L1 inhibitor V 是一种 human PD-1 protein 结合肽，Kd 值为 3.32 μM，可抑制人 PD-1/PD-L1 的结合。

Human PD-L1 inhibitor Vamp;;

Human PD-L1 inhibitor V Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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Human PD-L1 inhibitor V 的其他形式现货产品:

Human PD-L1 inhibitor V TFA

生物活性

Human PD-L1 inhibitor V, a human PD-1 protein binding peptide with a Kd value of 3.32 μM. Human PD-L1 inhibitor V inhibit the interaction of hPD-1/hPD-L1[1].

IC50 Target

Kd: 3.32 μM (Human PD-1 protein)[1]
体外研究
(In Vitro)

Human PD-L1 inhibitor V (Ar5M_2) is a peptide designed with anchor residues Y56, R113, A121, D122 and Y123[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1485.71

Formula

C65H104N20O18S
Sequence

Leu-Asp-Tyr-Val-Asn-Arg-Arg-Lys-Met-Tyr-Gln
Sequence Shortening

LDYVNRRKMYQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Qiao Li, et al. Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor. Oncotarget. 2016 Oct 4;7(40):64967-64976.