OM99-2 TFA

发表于由

OM99-2 TFA;

OM99-2 TFA，一种八残基拟肽，人脑 memapsin 2 的紧密结合抑制剂，其 Ki 值为 9.58 nM。OM99-2 TFA 显著促进了 BACE1 抑制剂的开发，具有研究阿尔茨海默症的潜力。

OM99-2 TFAamp;;

OM99-2 TFA Chemical Structure

CAS No. : 2504147-81-1

规格 是否有货
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生物活性

OM99-2 TFA, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM[1]. OM99-2 TFA is significantly advanced the development of BACE1 inhibitor[2]. OM99-2 has the potential for the research of the Alzheimer’s disease[3].

IC50 Target

Ki: 9.58 nM (memapsin 2)
体外研究
(In Vitro)

Memapsin 2 (BACE) is an aspartyl protease known as beta-secretase that acts on the production of the beta-amyloid peptide in the human brain[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1007.02

Formula

C43H65F3N8O16
CAS 号

2504147-81-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J Am Chem Soc. 2000;122(14):3522-3523.

    [2]. Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer’s Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4.

    [3]. Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38(2):89-119.

    [4]. Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125(52):16416-16422.