Argifin

Argifin;

Argifin 是一种由土壤微生物产生的次纳摩尔级别的几丁质酶 (chitinase) 抑制剂,对粘质沙雷菌几丁质酶 A 和 B、烟曲霉几丁质酶 B1 和人壳三糖酶作用的 IC50 值分别为 0.025 μM、6.4 μM、1.1 μM 和 4.5 μM。

Argifinamp;;

Argifin Chemical Structure

CAS No. : 243975-37-3

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生物活性

Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively[1].

IC50 Target

IC50: 0.025 μM (SmChiA), 6.4 μM (SmChiB), 1.1 μM (Aspergillus fumigatus chitinase B1), 4.5 μM (human chitotriosidase)[1]

体外研究
(In Vitro)

Argifin inhibits L. cuprina chitinase with IC50 values of 3.7 μM at 37 ºC and 0.10 μM at 20 ºC[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Argifin has the ability to inhibit L. cuprina molting[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

675.69

Formula

C29H41N9O10

CAS 号

243975-37-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hirose T, et al. Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soil microorganisms. Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(2):85-102.