TfR-T12

TfR-T12;

TfR-T12 是一个能透过血脑屏障的转铁蛋白受体 (TfR) 的结合肽,显示出 nM 水平的结合活性。

TfR-T12amp;;

TfR-T12 Chemical Structure

CAS No. : 344618-30-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

TfR-T12 的其他形式现货产品:

TfR-T12 TFA

生物活性

TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range[1][2].

体外研究
(In Vitro)

TfR-T12 binds to the TfR and is subsequently internalized into TfR-expressing cells[1].
TfR-T12 is a synthetic peptide obtained by phage display, and is able to bind a different site on TfRs compared with transferrin. TfR-T12 can be chemically conjugated with a pegylated lipid derivative, 3-(N-succinimidyloxyglutaryl)aminopropyl- polyethyleneglycol(2000)- carbamyl distearoyl phosphatidylethanolamine (NHS-PEG2000-DSPE), and used as a functional material to construct the multifunctional lipid vesicles[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1490.73

Formula

C71H99N19O15S

CAS 号

344618-30-0

Sequence

Thr-His-Arg-Pro-Pro-Met-Trp-Ser-Pro-Val-Trp-Pro

Sequence Shortening

THRPPMWSPVWP

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Carmen Wängler, et al. In Vitro and Initial in Vivo Evaluation of (68)Ga-labeled Transferrin Receptor (TfR) Binding Peptides as Potential Carriers for Enhanced Drug Transport Into TfR Expressing Cells. Mol Imaging Biol. 2011 Apr;13(2):332-41.

    [2]. Li-Min Mu, et al. Lipid Vesicles Containing Transferrin Receptor Binding Peptide TfR-T 12 and Octa-Arginine Conjugate stearyl-R 8 Efficiently Treat Brain Glioma Along With Glioma Stem Cells. Sci Rep. 2017 Jun 14;7(1):3487.