Pep2m, myristoylated(Synonyms: Myr-Pep2m)

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Pep2m, myristoylated;(Synonyms: Myr-Pep2m)

Pep2m, myristoylated (Myr-Pep2m) 是一种细胞通透性肽。Pep2m, myristoylated (Myr-Pep2m) 能破坏蛋白激酶 ζ (PKMζ) 下游靶点 NSF/GluR2 相互作用。PKMζ 具有自主活性的 PKC 同工酶。

Pep2m, myristoylatedamp;;(Synonyms: Myr-Pep2m)

Pep2m, myristoylated Chemical Structure

CAS No. : 1423381-07-0

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Pep2m, myristoylated 的其他形式现货产品:

Pep2m, myristoylated TFA

生物活性

Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC)[1][2].

IC50 Target

NSF/GluR2 interactions[1]
体外研究
(In Vitro)

Pep2m, myristoylated (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation[1].
Pep2m, myristoylated does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance, indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis[1].
Pep2m, myristoylated blocks NSF/GluR2-mediated AMPAR trafficking, and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Pep2m, myristoylated (10 µg/20 µL) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female and male Long-Evans hooded rats (8 weeks)[2]
Dosage: 10 µg (in 20 µL)
Administration: Intrathecal injection
Result: Resulted in an increase in PWTs, in both male and female rats at various time points tested.

分子量

1383.81

Formula

C14H27K3NOV
CAS 号

1423381-07-0
Sequence Shortening

{Myr}-KRMKVAKNAQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yudong Yao, et al. PKMζ Maintains Late Long-Term Potentiation by N-Ethylmaleimide-Sensitive Factor/GluR2-Dependent Trafficking of Postsynaptic AMPA Receptors. J Neurosci. 2008 Jul 30; 28(31): 7820-7827.

    [2]. Nicole C George, et al. Sex differences in the contributions of spinal atypical PKCs and downstream targets to the maintenance of nociceptive sensitization. Mol Pain. 2019; 15: 1744806919840582.