Hexa-D-arginine TFA;(Synonyms: Furin Inhibitor II TFA)
Hexa-D-arginine TFA (Furin Inhibitor II TFA) 是一种稳定的 furin 抑制剂，对 furin，PACE4 和 PC1 的 Ki 值分别为 106 nM，580 nM 和 13.2 μM。Hexa-D-arginine TFA 在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。
Hexa-D-arginine TFA Chemical Structure
CAS No. : 958204-56-3
| 规格 | 是否有货 | ||
|---|---|---|---|
| 100 mg | ; | 询价 | ; |
| 250 mg | ; | 询价 | ; |
| 500 mg | ; | 询价 | ; |
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Hexa-D-arginine TFA 的其他形式现货产品:
| 生物活性 |
Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3]. |
IC50 Target |
Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)[3] |
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| 体外研究 (In Vitro) |
Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| 体内研究 (In Vivo) |
Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
1068.17 |
| Formula |
C38H76F3N25O8 |
| CAS 号 |
958204-56-3 |
| Sequence |
Arg-Arg-Arg-Arg-Arg-Arg-NH2 |
| Sequence Shortening |
RRRRRR-NH2 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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