TRV055;
TRV055 是 1 型血管紧张素 II 受体 (AT1R) 的 Gq-偏置的配体。TRV055 有效刺激细胞 Gq 介导的信号传导。TRV055 可用于开发 Gq-偏置的 AT1R 激动剂。
TRV055 Chemical Structure
CAS No. : 25849-90-5
| 规格 | 是否有货 | ||
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| 100 mg | ; | 询价 | ; |
| 250 mg | ; | 询价 | ; |
| 500 mg | ; | 询价 | ; |
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| 生物活性 |
TRV055 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling. TRV055 can be used to develop the Gq-biased AT1R agonists[1]. |
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| 体外研究 (In Vitro) |
TRV055 is a “gain-of-function” ligand that have >10-fold greater allosteric coupling to Gq than AngII and is also more efficacious in stimulating cellular Gq-mediated signaling (e.g., IP1 generation). Compared to the endogenous ligand angiotensin II (AngII), “Gq-biased” AT1R agonists are more efficacious in stimulating Gq-mediated cellular signaling and in allosterically promoting Gq coupling[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
831.96 |
| Formula |
C42H57N9O9 |
| CAS 号 |
25849-90-5 |
| Sequence Shortening |
GVYIHPF |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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